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Image Search Results
Journal: Frontiers in Immunology
Article Title: Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization
doi: 10.3389/fimmu.2025.1551892
Figure Lengend Snippet: Cimifugin affects JAK1/STAT1 protein expression in colon and lung tissues of UC mouse models. (A) KEGG enrichment analysis of DEGs in colon. (B) KEGG enrichment analysis of DEGs in lung tissues. (C–E) Expression levels of JAK1 and STAT1 proteins in colon and lung tissues of different groups of mice (n = 3). Con, Control group; UC, Ulcerative colitis group; CIM,: Cimifugin group; JAK1, Janus kinase 1; STAT1, Signal Transducer and Activator of Transcription 1. ** P < 0.01.
Article Snippet:
Techniques: Expressing, Control
Journal: Frontiers in Immunology
Article Title: Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization
doi: 10.3389/fimmu.2025.1551892
Figure Lengend Snippet: Cimifugin regulates M1 polarization in macrophages by inhibiting activation of the JAK1/STAT1 pathway. (A) Effects of different concentrations of cimifugin on the phosphorylation of JAK1 and STAT1 in an in vitro model. (B) Analysis of grayscale values corresponding to p-JAK1 and p-STAT1. (C) Expression levels of the corresponding markers after treatment with cimifugin and Upadacitinib. (D–G) Analysis of grayscale values corresponding to various markers (iNOS, IL-1β, Arg1, CD206). (H, I) Concentrations of IL-6 and TNF-α in different groups. Con, Control group; LPS, Lipopolysaccharide; Cim, Cimifugin; CIM-H, High-dose cimifugin group; CIM-M, Medium-dose cimifugin group; CIM-L, Low-dose cimifugin group; IL-6, Interleukin - 6; IL-1β, Interleukin-1 beta; TNF-α, Tumor necrosis factor-alpha; JAK1, Janus kinase 1; STAT1, Signal Transducer and Activator of Transcription 1; iNOS, inducible nitric oxide synthase; CD206, Cluster of Differentiation 206; Arg1, arginase 1. N = 3, * P < 0.5; ** P < 0.01.
Article Snippet:
Techniques: Activation Assay, Phospho-proteomics, In Vitro, Expressing, Control